Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. https://naturalmedicines.therapeuticresearch.com. If you have an underactive thyroid gland. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Moderately clinically significant. Isosorbide mononitrate helps to prevent angina chest pain from developing. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Upgrade to Patient Pro Medical Professional? Theyre fast, easy-to-use and free! Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. These products are provided 'AS IS' and 'as available' for use, without warranties of any kind, either express or implied. This does not necessarily mean no interactions exist. It can make you really dizzy. This content does not have an Arabic version. Canada residents can call a provincial poison control center. Natural Medicines. Tolerance is more likely to happen if you don't take your dose at the same time every day. If headaches continue or become severe, tell your doctor promptly. (2) One in 3 patients never experienced headache from the given dosages. If you miss a dose, take it as soon as you remember. 2023 eHealthMe.com. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Isosorbide mononitrate has an average rating of Isosorbide mononitrate systemic 60 mg (A ID). Highly clinically significant. Some don't work well with prescription medicines. Some of these medicine interactions can be risky. Ask your doctor before using aspirin together with alcohol. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. 8.0 out of 10 from a total of However, you should not flush this medication down the toilet. Be sure to talk to your health care provider before you take any herbal supplements if you take prescription medicines. Do not share this medication with others. Clipboard, Search History, and several other advanced features are temporarily unavailable. Am J Ther. 2005 - 2023 WebMD LLC. Some of these interactions can be life-threatening. Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure. Bauer B (expert opinion). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Careers. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Try to keep your regular appointments with your doctor. We study millions of patients and 5,000 more each day. Herbal medications in cardiovascular medicine. Accessed Sept. 7, 2022. 41% of reviewers reported a positive effect, while 50% reported a negative effect. This is so your doctor can check on your progress. Does isosorbide mononitrate (Monoket) affect your kidneys? Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. The dose is according to the body weight and severity of the condition. Contact your doctor immediately if you experience any of the following: The following side effects may get better over time as your body gets used to the medication. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Should I avoid certain foods while taking Isosorbide Mononitrate? As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. This document does not contain all possible drug interactions. A single copy of these materials may be reprinted for noncommercial personal use only. Side effects : headache, mild dizziness Isosorbide mononitrate (Monoket) is not known to affect the kidneys. My EKG showed Assess your symptoms online with our free symptom checker. Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with heart failure. Overview of herbal medicines and dietary supplements. If you have any problems with the way your liver works, or any problems with the way your kidneys work. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Of the total drug interactions, Danshen. Advertising revenue supports our not-for-profit mission. While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. Herbal supplements can strongly affect the body. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. Ask your pharmacist any questions you have about refilling your prescription. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . The information on this page is written and peer reviewed by qualified clinicians. Below is the list of medicines, which contains Isosorbide Mononitrate as ingredient. Evening primrose. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Do not take more or less of it or take it more often than prescribed by your doctor. You may report side effects to Health Canada at 1-866-234-2345. Even if the medication is working, you may experience some unwanted side effects. Isosorbide mononitrate belongs to the group of medicines called nitrates. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. The extended-release tablet usually is taken once daily in the morning. Keep all medications away from children and pets. May also be prescribed off label for Esophageal Spasm. Herbal supplements are natural, so they must be safe, right? What are the interactions of Isosorbide Mononitrate ? Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. If you notice any other effects, check with your healthcare professional. All rights reserved. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. In Canada - Call your doctor for medical advice about side effects. Talk to your pharmacist for more details. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Natural Medicines. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. The herb licorice may lower warfarin levels and can add to digoxin's effects. The most common side-effect is headache. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Unauthorized use of these marks is strictly prohibited. Select a condition to view a list of medication options. See also: aspirin side effects in more detail. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. Drug interactions may change how your medications work or increase your risk for serious side effects. URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. This information is aggregated and used to produce personalized reports that patients can reference. The https:// ensures that you are connecting to the It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. In: Current Medical Diagnosis & Treatment 2022. isosorbide mononitrate prices. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. To provide you with the most relevant and helpful information, and understand which Garlic. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. The short-acting tablet is usually taken as 10 mg to 40 mg by mouth 2 or 3 times daily with at least a 14 hour period of time per day where you don't take any doses. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Using this medicine with any of the following medicines is not recommended. Do not keep out-of-date or unwanted medicines. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. Along with its needed effects, a medicine may cause some unwanted effects. Treatment and prognosis of heart failure with preserved ejection . What special dietary instructions should I follow? It is not intended as medical advice for individual conditions or treatment. All rights reserved. Is isosorbide mononitrate (Monoket) the same as nitroglycerin (Nitrostat)? Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. https://naturalmedicines.therapeuticresearch.com. I would rather take the chance of a heart attack than have no quality of life. Take extra precautions to avoid falling during your treatment with isosorbide. It works by . Portions of this document last updated: Feb. 01, 2023. Glyceryl trinitrate (GTN) is commonly prescribed for this. Conclusions: Generic alternatives may be available. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. It will not treat an angina attack that has already begun. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Real test is coronary angiography. The most common side-effect is headache. https://naturalmedicines.therapeuticresearch.com. Drug information provided by: IBM Micromedex. What are the side effects of Isosorbide Mononitrate ? There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. Integrative medicine (complementary and alternative medicine). This site complies with the HONcode standard for trustworthy health information: verify here. You can consult me online for homeopathic treatment. Learn to reduce stress through mindful living. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). In the remainder of them there was a highly significant time effect: the overall numbers of headache attacks in the first period of active treatment versus the second were 2,380 vs 1,400 (P < 0.003). GoodRx works to make its website accessible to all, including those with disabilities. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. other information we have about you. . Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Before The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). If you have ever had an allergic reaction to a medicine. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. This is called tolerance, and it cannot be fixed by raising the dose of the medication. In: Textbook of Natural Medicine. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Accessed Sept. 7, 2022. Do not store in the bathroom. Accessed Sept. 7, 2022. AHFS Patient Medication Information. 2023 Lybrate, Inc. All rights reserved. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. If you have an eye condition called glaucoma. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. Natural Medicines. What should I know about storage and disposal of this medication? 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Isosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. It does not have such side effects. Mayo Clinic does not endorse companies or products. privacy practices. 1998 Oct;61(10):577-83. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). Receive price alerts, news, and other messages from GoodRx about isosorbide mononitrate (Monoket) and other healthcare topics and relevant savings offers. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Dated October 2016. Journal of the American College of Cardiology. What special precautions should I follow? It might help to keep the room cool and use a fan. Accessed Sept. 7, 2022. This content does not have an English version. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. [2] It is taken by mouth. View more. This makes it easier for your heart to pump, relieving heart-related chest pain. If you become pregnant while taking isosorbide, call your doctor. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. http://www.upandaway.org. Copyright 2023 IBM Watson Health. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease.. Side effects of Imdur and Isordil that are similar include headache and dizziness.. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. Call your doctor for medical advice about side effects. Never take more than the prescribed dose. Many common herbal supplements interact with common heart medicines. The IR version can help treat and prevent angina. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. Reduction of blood-nitrate concentrations to low levels for 4 to 12 hours each day usually maintains effectiveness in such patients. and transmitted securely. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. Medicines containing Isosorbide Mononitrate. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). Elsevier; 2021. https://www.clinicalkey.com. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Does Viagra add to the risks of melanoma? Valerian: A safe and effective herbal sleep aid? Store at room temperature away from light and moisture. https://naturalmedicines.therapeuticresearch.com. Make sure laboratory personnel and all your doctors know you use this drug. Accessed Sept. 7, 2022. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Eur Heart J. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). No, that's not true all the time. This is a condition where the heart does not beat as efficiently as it should. Can cause dizziness, especially when you change positions, Interacts with erectile dysfunction medications. We study 23,548 Isosorbide mononitrate users. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Always consult your healthcare provider. Generic alternatives may be available. Isosorbide mononitrate belongs to the group of medicines called nitrates. Take this medication by mouth as directed by your doctor, usually twice a day. Along with its needed effects, a medicine may cause some unwanted effects. Mayo Clinic. Talk to your doctor about the possible risks of using this medication for your condition. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Talk to your doctor if you are using marijuana (cannabis). If you suffer headaches when taking Isosorbide mononitrate, be patient. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Usually avoid combinations; use it only under special circumstances. Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. There may be variations in CSA schedules between individual states. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Accessed Sept. 7, 2022. Using this medicine with any of the following medicines is not recommended. Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. 55 ratings on Drugs.com. As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy. Botanical medicine A modern perspective. https://naturalmedicines.therapeuticresearch.com. If your chest pain attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor.