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Women are 50% more likely to develop pityriasis rosea. Outcome: However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days. Zendaya Shows Off Her Short Sunshine Curls. Bethesda, MD 20894, Web Policies 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). (2020) 33:e13650. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). The .gov means its official. (a) haematoxylineosin, original magnification 10. Authors B M Cyrenne 1 , F Al-Mohammedi 1 , J G DeKoven 1 , R Alhusayen 1 Affiliation Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). You may initially develop a fever, headache or upper respiratory infection. 2021 Nov 2;17(11):4097-4098. doi: 10.1080/21645515.2021.1963173. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. Learning points: -, Mahajan K, Relhan V, Relhan AK, et al. This site needs JavaScript to work properly. Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. Curr Dermatol Rep. 2022;11(4):289-312. doi: 10.1007/s13671-022-00370-9. Accessibility Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. J Eur Acad Dermatol Venereol. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. A 3-cm oval plaque with peripheral scale, larger than the other lesions, was present on the inferior portion of the right breast. Unable to load your collection due to an error, Unable to load your delegates due to an error. The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. Bookshelf Patient concerns: PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). Clipboard, Search History, and several other advanced features are temporarily unavailable. Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. "Other treatments including phototherapy or oral medications can be considered for extensive or persistent cases, [and] some small case studies support the use of oral antivirals like acyclovir or oral anti-inflammatory antibiotics erythromycin," King explains. Australas J Dermatol. 2005;124(6):12341240. Develop a large patch on your skin. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). The authors have no conflicts of interests to disclose. Epub 2021 May 29. J Eur Acad Dermatol Venereol. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pityriasis rosea: An update on etiopathogenesis and management of difficult aspects. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. eCollection 2022. Epub 2021 May 29. eCollection 2022. Bethesda, MD 20894, Web Policies Children often get infected when someone sneezes or kisses them. Epub 2022 Jun 19. In approximately 50% of people with pityriasis rosea, the patches itch. This site needs JavaScript to work properly. It should clear your body in six to eight weeks. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. government site. Clipboard, Search History, and several other advanced features are temporarily unavailable. See this image and copyright information in PMC. Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). (2021) 93:18501. (c) Patient 2: Thin red to tan oval plaques with peripheral scale on the trunk and proximal thigh. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. Medicine (Baltimore). Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. Disclaimer. -, Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosealike eruptions: how to distinguish them? Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Disclaimer. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). National Library of Medicine Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. At first, I thought it was a mosquito bite. Some people who have had cosmetic fillers used to remove . World J Clin Cases. 8 PDF Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases D. McMahon, E. Amerson, +11 authors E. Freeman Medicine Before Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. J Eur Acad Dermatol Venereol 2020;34:e4367. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Luckily, it's not contagious. How quickly did it come on, and did my boyfriend also have it? PR is a rare cutaneous reaction after mRNA vaccination against SARS-CoV-2. PMC An official website of the United States government. Epub 2021 Jun 10. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Studies show that some skin conditions may appear with COVID-19, including pityriasis rosea. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. eCollection 2022. Cutis. N Engl J Med 2020; 383: 2603-2615. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). -, Neoh CY, Tan AW, Mohamed K, et al. Epub 2020 Nov 20. Please enable it to take advantage of the complete set of features! (2006) 12:1. doi: 10.5070/D380D8301D, 11. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Bookshelf 6 Called a "herald patch,". Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. Figure 1. Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. doi: 10.1111/dth.15601. You cant spread pityriasis rosea to another person through unprotected sex or skin-to-skin contact. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. Though there's no single-known cause, it may be brought on by a drug interaction, or the reactivation of herpes simplex virus 6 or 7. Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID19: a preliminary review of an emerging issue. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. J Invest Dermatol. To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). (2021) 85:4655. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). No use, distribution or reproduction is permitted which does not comply with these terms. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. 2021;185(2):e34. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Epub 2022 Feb 9. sharing sensitive information, make sure youre on a federal Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Epub 2021 Aug 26. Lessons: Unauthorized use of these marks is strictly prohibited. These types cannot cause cold sores or genital herpes. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. Your California Privacy Rights. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Studies show that the development of pityriasis rosea during pregnancy may cause birth complications, including miscarriage and poor muscle tone and development once the baby is born (neonatal hypotonia). FOIA These strains of the herpes virus arent related to the strains that cause cold sores or genital herpes. The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. J Am Acad Dermatol. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. A case of Pityriasis rosea is presented in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. doi: 10.1111/jdv.17498. Bookshelf Oily fish, such as mackerel, salmon or sardines. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. See this image and copyright information in PMC. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." How long will it take my body to clear the rash? and transmitted securely. J Am Acad Dermatol. Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. Advertising on our site helps support our mission. HHS Vulnerability Disclosure, Help Epub 2022 Jun 8. We do not endorse non-Cleveland Clinic products or services. Authors Lina Abdullah 1 This reaction is self-limited and resolves in an average of 5.6 weeks. doi: 10.7759/cureus.27108. Pityriasis rosea is also known as Christmas tree rash. Herein, we are reporting a unique. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This site needs JavaScript to work properly. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Federal government websites often end in .gov or .mil. official website and that any information you provide is encrypted Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. Epub 2022 Jun 21. 2021 Aug;185(2):e34. Careers. Inverse pityriasis rosea secondary to COVID-19 vaccination. Refined carbohydrates, such as sugar, pastries and white bread. What at-home treatments do you recommend? government site. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. doi: 10.7759/cureus.22414. Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. What started as a single, quarter-inch raised welt on my left rib cage eventually morphed into two, then four. doi: 10.1111/jdv.17316. JAAD Int. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. Pityriasis rosea-like eruption revealing COVID-19. 8 In some cases, antibodies against HHV6/7 as well as viral DNA in plasma and PBMCs were detected. doi: 10.1111/ajd.13504. government site. Epub 2020 Jun 5. The .gov means its official. Epub 2022 May 3. "It looks very different.". The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. Pityriasis rosea. J Eur Acad Dermatol Venereol. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. eCollection 2022. J Am Acad Dermatol. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Even though it is benign, it can cause substantial. Treatment may include various topical and oral drugs. HHS Vulnerability Disclosure, Help One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. Flares of other types of skin conditions [like psoriasis] sometimes have been described as well," says Lam. Europe PMC is an archive of life sciences journal literature. 2021 Aug;185(2):e34. Careers. Pityriasis rosea and pityriasis rosea-like eruptions after COVID-19 vaccines. Please enable it to take advantage of the complete set of features! Br J Dermatol 2020; 183: 431442. Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. Had I started new medication? No one knows what causes pityriasis rosea, though healthcare experts think a virus might be responsible. Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study. Epub 2022 Jun 21. 2021 Sep;35 (9):e546-e548. If you have a very itchy rash, your healthcare provider may prescribe the following to help relieve your symptoms: There are several over-the-counter products or home remedies that can help stop your rash from itching. Before Clipboard, Search History, and several other advanced features are temporarily unavailable. Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. However, several adverse effects of COVID-19 vaccination have been identified. Cureus. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Epub 2022 Jan 5. Although the exact pathogenesis of PR remains unknown, the endogenous systemic reactivation of HHV (i.e., type 6 and 7) in the skin has been implicated as a precipitating factor. 1. Clin Exp Dermatol 2010;35:3004. Dermatol Ther. Vaccinations have been identified to rarely cause several cutaneous reactions. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination.